Unleash Full Potential of Resveratrol

Lab researcher working on combining grape derived resveratrol and hydrogel fiber

Unleash Full Potential of Resveratrol

Resveratrol, when combined with hydrogel fiber, becomes up to 10 times more bioavailable, delivering longevity effects throughout the body.

Scientifically reviewed by: Dr. Gary Gonzalez, MD, in December 2022. Written by: Alan Bell.

Life Extension Health Concens

Resveratrol is one of those nutrients that is a multi-tasker.1-3

It has potential to increase longevity and promote better cardiovascularbrain, and metabolic health.1-3

One challenge with resveratrol has been finding ways to make it more bioavailable.

Despite having good initial absorption, resveratrol is rapidly metabolized, leaving little of the original compound circulating in blood.

Scientists have made an advance in improving resveratrol delivery.

Formulating it into a hydrogel fiber blend enables up to 10 times greater bioavailability compared to unformulated resveratrol.4

This enhances the amount and time that resveratrol can deliver its multiple benefits throughout the body.

Resveratrol Bioavailability

Resveratrol is a polyphenol compound found in several plants, most notably red grapes, some berries, and Japanese knotweed.

In its free form, resveratrol has poor bioavailability.4-6 Most of the free resveratrol does not end up in the bloodstream and cannot get to the tissues where it can exert beneficial effects.

The main reason is that active resveratrol is rapidly metabolized.4-6

Protecting Against Rapid Degradation

Researcher dividing samples into vial for resveratrol rapid metabolism protection

Researchers discovered that a plant fiber formulation can protect resveratrol from rapid metabolism, greatly enhancing its bioavailability and delivery to tissues.4

Galactomannans are a plant-derived, indigestible fiber. Human enzymes cannot break this fiber down.

Embedding resveratrol in a matrix of these fibers creates a hydrogel that protects the resveratrol from rapid degradation in the liver and digestive tract.

In a recent trial, human subjects were randomized to receive either this new hydrogel form of resveratrol or the same dose of regular unformulated resveratrol.4 The new formulation increased bioavailability of resveratrol by more than 10 times.

In addition, the hydrogel resveratrol resulted in almost four-fold greater peak blood levels of resveratrol and nearly a four-fold greater half-life. That means the new resveratrol reached higher levels in the body and stayed in the bloodstream longer.

Why Resveratrol Is Biologically Important

Cells undergoing several processes that resveratrol impacts

Resveratrol is a phytonutrient that impacts several cellular processes.

For example, it activates:2,3

Through its impact on these and other systems, resveratrol helps prevent or mitigate several different forms of chronic disorders.

Resveratrol’s actions also mimic some beneficial actions found with calorie-restricted diets and exercise, which both improve metabolic health.

Through its various actions, resveratrol provides a broad array of benefits that can help improve insulin sensitivity, activate longevity genes, and reduce chronic inflammation.2,3

Multifaceted Effects

The effects of resveratrol extend to practically every organ system.

Among the potential benefits observed in a wide range of studies, resveratrol has been shown to:

With greater bioavailability, hydrogel resveratrol can maximize the potential to achieve these types of benefits.


Ground dried grapes containing poor bioavailable resveratrol

A Better Resveratrol at Last


Mature couple taking photo

Resveratrol has shown an ability in preclinical models and in different types of organisms to prolong life as well as to dampen an array of pathologic mechanisms.

In humans, resveratrol has been studied to target a number of disease mechanisms.

Poor bioavailability of resveratrol has long been an issue, but a new hydrogel formulation protects it, allowing greater bioavailability.

A clinical study has shown that this hydrogel resveratrol offers up to 10 times greater bioavailability than unformulated resveratrol.

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